Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry
نویسندگان
چکیده
منابع مشابه
A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry.
Vismodegib (GDC-0449), a small-molecule Hedgehog pathway inhibitor, was well tolerated in patients with solid tumors and showed promising efficacy in advanced basal cell carcinoma in a Phase I trial. The purpose of the study presented here was to determine routes of elimination and the extent of vismodegib metabolism, including assessment and identification of metabolites in plasma, urine, and ...
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ژورنال
عنوان ژورنال: Investigational New Drugs
سال: 2007
ISSN: 0167-6997,1573-0646
DOI: 10.1007/s10637-007-9041-z